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海洋天然化合物
研究計劃資料
計畫名稱 : 海洋天然化合物
研究人員 : 宋秉鈞(計劃主持人)、郭傑民、蘇瑞欣、呂美津
子計畫 :
1. 海洋無脊椎動物及養殖型八放珊瑚所含天然物成份 之研究 (宋秉鈞)
2. 產天然物之海洋微生物篩選 (郭傑民)
3. 八放珊瑚和海綿所含活性物質的研究及探討相關衍 生物的生物活性 (蘇瑞欣)
4. 海洋天然物抗癌活性之篩選及其作用之評估 (呂美津)

計劃說明 :
在過去六十多年來,從事海洋天然物的研究學者從細菌、真菌、微藻、海藻、海綿和軟珊瑚等物種已找到2萬以上的海洋天然化合物,而這些海洋天然物中有許多化合物具有獨特的結構和良好的生物活性,其中有數個化合物被預望具有潛力的藥物或是做為先導的藥物。而本計畫之主要目的是從臺灣海域中的海洋無脊椎動物和海洋微生物找尋具有藥用的海洋天然物。

研究成果 :
Chen, W.-F.; Yin, C.-T.; Cheng, C.-H.; Lu, M.-C.; Fang,
L.-S.; Wang, W.-H.; Wen, Z.-H.; Chen, J.-J.; Wu, Y.-C.*; Sung, P.-J.* Norcembranoidal diterpenes from the cultured-type octocoral Sinularia numerosa. Int. J. Mol. Sci. 2015, 16, 3298–3306.
Su, Y.-D.; Su, T.-R.; Wen, Z.-H.; Hwang, T.-L.; Fang, L.-S.; Chen, J.-J.; Wu, Y.-C.; Sheu, J.-H.*; Sung, P.-J.* Briarenolides K and L, new anti-inflammatory briarane diterpenoids from an octocoral Briareum sp. (Briareidae). Mar. Drugs 2015, 13, 1037-1050.
Chung, H.-M.; Wang, W.-H.; Hwang, T.-L.; Wu, Y.-C.*; Sung, P.-J.* Natural caryophyllane sesquiterpenoids from Rumphella antipathies. Nat. Prod. Commun. 2015, 10, 835-838.
Lin, S.-W.; Huang, S.-C.; Kuo, H.-M.; Chen, C.-H.; Ma, Y.-L.; Chu, T.-H.; Bee, Y.-S.; Wang, E.-M.; Wu, C.-Y.; Sung, P.-J.; Wen, Z.-H.; Wu, D.-C.; Sheu, J.-H.*; Tai, M.-H.* Coral-derived comnpound WA-25 inhibits angiogenesis by attenuating the VEGF/VEGFR2 signaling pathway. Mar. Drugs 2015, 13, 861–878.
Chen, J.-J.; Lee, T.-H.; Kuo, W.-L.; Sung, P.-J.; Chen, I.-S.; Shu, C.-W.; Cheng, M.-J.; Wang, T.-C.; Lim, Y.-P.; Xu, R. (+)-(6aR,7R)-7-Hydroxy-N-butyrylcaaverine, a new aporphine alkaloid from the root of Illigera luzonensis with cytotoxic activity. Chem. Nat. Comp. 2015, 51, in press.
Lien, J.-C.; Huang, C.-C.; Lu, T.-J.; Tseng, C.-H.; Sung, P.-J.; Lee, H.-Z.; Bao, B.-Y.; Kuo, Y.-H.; Lu, T.-L. Naphthoquinone derivative PPE8 induces endoplasmic reticulum stress in p53 Null H1299 cells. Oxid. Med. Cell Longev. 2015, doi:10.1155/2015/453679.
Chen, J.-J.*; Kuo, W.-L.; Sung, P.-J.; Chen, I.-S.; Cheng, M.-J.; Lim, Y.-P.; Liao, H.-R.; Chang, T.-H.; Wei, D.-C.; Chen, J.-Y. Beilschamide, a new amide, and cytotoxic constituents of Beilschmiedia erythrophloia. Chem. Nat. Comp. 2015, 51, 302–305.
Chen, J.-J.*; Yang, C.-K.; Kuo, Y.-H.; Hwang, T.-L.; Kuo, W.-L.; Lim, Y.-P.; Sung, P.-J.; Chang, T.-H.; Cheng, M.-J. New coumarin derivatives and other constituents from the stem bark of Zanthoxylum avicennae: effects on neutrophil pro-inflammatory responses. Int. J. Mol. Sci. 2015, 16, 9719–9731.
Liu, K.-M.; Cheng, C.-H.; Chen, W.-F.; Lu, M.-C.; Fang, L.-S.; Wen, Z.-H.; Su, J.-H.; Wu,
Y.-C.*; Sung, P.-J.* Trocheliolide A, a hydroperoxycembranoidal diterpene from the octocoral Sarcophyton trocheliophorum. Nat. Prod. Commun. 2015, 10, 1163–1165.
Huang, T.-Z.; Chen, B.-W.; Huang, C.-Y.; Hwang, T.-L.; Uvarani, C.; Dai, C.-F.; Sung, P.-J.; Su, J.-H.; Sheu, J.-H.* Eunicellin-based diterpenoids, hirsutalins S–V, from the Formosan soft coral Cladiella hirsuta. Mar. Drugs 2015, 13, 2757–2769.
Lin, Y.-Y.; Lin, S.-C.; Feng, C.-W.; Chen, P.-C.; Su, Y.-D.; Li, C.-M.; Yang, S.-N.; Jean, Y.-H.; Sung, P.-J.; Duh, C.-Y.*; Wen, Z.-H.* Anti-inflammatory and analgesic effects of the marine-derived compound excavatolide B isolated from the culture type Formosan Gorgonian Briareum excavatum. Mar. Drugs 2015, 13, 2559–2579.
Shih, S.-P.; Lee, M.-G.; El-Shazly, M.; Juan, Y.-S.; Du, Y.-C.; Su, J.-H.; Sung, P.-J.; Chen, Y.-C.; Yang, J.-C.; Wu, Y.-C.*; Lu, M.-C.* Tackling the cytotoxic effect of a marine polycyclic quinone-type metabolite: halenaquinone induces apoptosis in leukaemia cancer cell lines via oxidative stress combined with the inhibition of HDAC and toposiomerase activities. Mar. Drugs 2015, 13, 3132-3153.
Chen, C.-C.; Kuo, Y.-H.; Cheng, J.-J.; Sung, P.-J.; Ni,
C.-L.; Chen, C.-C.; Shen, C.-C*. Three new
sesquiterpene aryl esters from the mycelium of
Armillaria mellea. Molecules 2015, 20, 9994–10003.
14. Hsiao, T.-H.; Sung, C.-S.; Lan, Y.-H.; Wang, Y.-C.; Lu, M.-C.; Wen, Z.-H.; Wu, Y.-C.*; Sung, P.-J.* New anti-inflammatory cembranes from the cultured soft coral Nephthea columnaris. Mar. Drugs 2015, 13, 3443–3453.
Wu, S.-Y.; Chang, Y.-L.; Pan, S.-L.; Teng, C.-M.*; Sung, P.-J. Heteronemin, a spongean sesterterpene, induces cell apoptosis and autophagy in human renal carcinoma cells. BioMed Res. Int. 2015, doi:10.1155/2015/738241.
Hsiao, T.-H.; Cheng, C.-H.; Wu, T.-Y.; Lu, M.-C.; Chen, W.-F.; Wen, Z.-H.; Dai, C.-F.; Wu, Y.-C.*; Sung, P.-J.* New cembranoid diterpenes from the cultured octocoral Nephthea columnaris. Molecules 2015, 20, in press.
Lai, Y.-Y.; Lu, M.-C.; Wang, L.-H.; Chen, J.-J.; Fang, L.-S.; Wu, Y.-C.*; Sung, P.-J.* New scalarane sesterterpenoids from the Formosan sponge Ircinia felix. Mar. Drugs 2015, 13, 4296–4309.
Yin, C.-T.; Wen, Z.-H.; Lan, Y.-H.; Chang, Y.-C.; Wu, Y.-C.*; Sung, P.-J.* New anti-inflammatory norcembranoids from the soft coral Sinularia numberosa. Chem. Pharm. Bull. 2015, accepted.
Su, T.-R.*; Liao, Z.-J.; Lu, M.-C.; Wu, Y.-J. Su, J.-H.* Cytotoxic Monocarbocyclic Sesterterpenoids from a Marine Sponge Luffariella sp. Bulletin of the Chemical Society of Japan, 2015, 88, 176–182.
Lin, Y.-Y.; Tsai, S.-J.; Chiang, M. Y.; Wen, Z.-H.*; Su, J.-H.* Anti-inflammatory Anthraquinones from the Crinoid Himerometra magnipinna. Nat. Prod. Comm. 2015, 10, 317-318.
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