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姓名:呂美津

職稱:特聘教授(特聘期間 2020年8月1日~2022年7月31日)

Emailjinx6609@gms.ndhu.edu.tw  ;  jinx6609@nmmba.gov.tw

聯絡方式:944屏東縣車城鄉後灣村後灣路二號

聯絡電話:(08)882-5001#1354

 

專長:抗癌天然物活性之研發、細胞生物學、藥效評估

 

國立海洋生物博物館研究人員

 

學歷:

高雄醫學大學 天然藥物研究所 博士 (2004/09 ~ 2008 / 07)

 

經歷:

國立東華大學海洋生物研究所   教授 (2017 /08 ~迄今)

國立東華大學海洋生物研究所   副教授 (2014 /08 ~2017 /07)

國立東華大學海洋生物科技研究所 副教授 (2014 /02 ~2014 /07)

國立東華大學海洋生物科技研究所 助理教授 (2010 /08 ~ 2014 /01)

國立海洋生物博物館企劃研究組  研究員 (2018 /08 ~迄今)

國立海洋生物博物館企劃研究組  副研究員 (2014 /08 ~2018/07)

國立海洋生物博物館企劃研究組  助理研究員 (2010 /08 ~2014/07)

高雄醫學大學天然藥物研究所   博士後研究 (2008 / 8 ~ 2010 / 07)

 


具匿名審查制度之期刊

Kuan-Chih Wang, Yi-Chang Liu, Mohamed El-Shazly, Shou-Ping Shih, Ying-Chi Du, Yu-Ming Hsu, Hung-Yu Lin, Yu-Cheng Chen, Yang-Chang Wu, Shyh-Chyun Yang, and Mei-Chin Lu*, The Antioxidant from Ethanolic Extract of Rosa cymosa Fruits Activates Phosphatase and Tensin Homolog In Vitro and In Vivo: A New Insight on Its Antileukemic Effect. International Journal of Molecular Sciences, 2019, Apr 19; 20(8). pii: E1935. (Impact factor: 4.183; Ranking: 46/172=26.75% in Chemistry, Medicinal, SCI)

Yu-Cheng Chen, Mei-Chin Lu, Mohamed El-Shazly, Kuei-Hung Lai, Tung-Ying Wu, Yu-Ming Hsu, Yi-Lun Lee, Yi-Chang Liu*, Breaking down Leukemia Walls: Heteronemin, a Sesterterpene Derivative, Induces Apoptosis in Leukemia Molt4 Cells through Oxidative Stress, Mitochondrial Dysfunction and Induction of Talin Expression. Marine Drugs, 2018, Jun 17; 16(6). pii: E212. (Impact factor: 3.772; Ranking: 5/59=23.77% in Chemistry, Medicinal, SCI) (Co-first author)

Man-Gang Lee, Yi-Chang Liu, Yi-Lun Lee, Mohamed El-Shazly, Kuei-Hung Lai, Shou-Ping Shih, Seng-Chung Ke, Ming-Chang Hong, Ying-Chi Du, Juan-Cheng Yang, Ping-Jyun Sung, Zhi-Hong Wen, and Mei-Chin Lu*, Heteronemin, a Marine Sesterterpenoid-Type Metabolite, Induces Apoptosis in Prostate LNcap Cells via Oxidative and ER Stress Combined with the Inhibition of Topoisomerase II and Hsp90. Marine Drugs, 2018, Jun 10; 16(6). pii: E204. (Impact factor: 3.772; Ranking: 5/59=23.77% in Chemistry, Medicinal, SCI) (Corresponding author)

Chih-Fung Wu, Man-Gang Lee , Mohamed El-Shazly, Kuei-Hung Lai, Seng-Chung Ke , Chiang-Wen Su, Shou-Ping Shih, Ping-Jyun Sung, Ming-Chang Hong, Zhi-Hong Wen and Mei-Chin Lu*, Isoaaptamine Induces T-47D Cells Apoptosis and Autophagy via Oxidative Stress. Marine Drugs, 2018, Jan 9; 16(1). pii: E18. (Impact factor: 3.772; Ranking: 5/59=23.77% in Chemistry, Medicinal, SCI) (Corresponding author)

Bo-Rong Peng, Mei-Chin Lu, Mohamed El-Shazly, Shwu-Li Wu, Kuei-Hung Lai and Jui-Hsin Su, Aquaculture Soft Coral Lobophytum crassum as a Producer of Anti-Proliferative Cembranoids. Marine Drugs, 2018, Jan 7; 16(1). pii: E15. (Impact factor: 3.772; Ranking: 5/59=23.77% in Chemistry, Medicinal, SCI)

 Elucidating Mechanisms of Bladder Repair after Hyaluronan Instillation in Ketamine-Induced Ulcerative Cystitis in Animal Model. The American Journal of Pathology, 2017 Sep; 187(9):1945-1959. (Impact factor: 3.762; Ranking: 11/79=13.93% in Pathology, SCI)

Chih-Hua Chao, Wen-Liang Li, Chiung-Yao Huang, Atallah F. Ahmed, Chang-Feng Dai, Yang-Chang Wu, Mei-Chin Lu, Chih-Chuang Liaw, and Jyh-Horng Sheu, Isoprenoids from the Soft Coral Sarcophyton glaucum, Marine Drugs, 2017, Jun 27;15 (7): pii: E202. (Impact factor: 3.772; Ranking: 5/59=23.77% in Chemistry, Medicinal, SCI)

Kuei-Hung Lai, Mei-Chin Lu, Ying-Chi Du, Mohamed El-Shazly, Tung-Ying Wu, Yu-Ming Hsu, Astrid Henz, Juan-Cheng Yang, Anders Backlund, Fang-Rong Chang, and Yang-Chang Wu, Cytotoxic Lanostanoids from Poria cocos, Journal of Natural Products, 2016, Nov 23;79 (11): 2805–2813. (Impact feactor:4.257; Ranking: 14/60=6.79% in Plant Sciences, SCI) (共同第一作者)

Kuei-Hung Lai, Yi-Chang Liu, Jui-Hsin Su, Mohamed El-Shazly, Chih-Fung Wu, Ying-Chi Du, Yu-Ming Hsu, Juan-Cheng Yang, Ming-Kai Weng, Chia-Hua Chou, Guan-Yu Chen, Yu-Cheng Chen, and Mei-Chin Lu, Antileukemic Scalarane Sesterterpenoids and Meroditerpenoid from Carteriospongia (Phyllospongia) sp., Induce Apoptosis via Dual Inhibitory Effects on Topoisomerase II and Hsp90, Scientific Reports, 2016, Oct 31; 6:36170. (Impact factor: 4.011; Ranking: 10/64=21.01% in Multidisciplinary science, SCI)(通訊作者)

Ta-Yuan Whuang, Wen-Cheng Tsai, Nan-Fu Chen, Zhi-Cheng Chen, Kuan-Hao Tsui, Zhi-Hong Wen, Yin-Di Su, Yu-Chia Chang, Yu-Hsin Chen, Mei-Chin Lu, Lee-Shing Fang, Jih-Jung Chen, Tung-Ying Wu, Yang-Chang Wu, and Ping-Jyun Sung, Columnaristerol A, a novel 19-norsterol from the Formosan octocoral Nephthea columnaris, Bioorganic & Medicinal Chemistry Letters, 2016, Oct 15;26:4966-4969. (Impact factor: 2.448; Ranking: 33/61=54.10% in chemistry, Organic, SCI)

Wu-Fu Chen, Yu-Chia Chang, Yuh-Wen Chiu, Lee-Shing Fang, Yu-Hsin Chen, Yin-Di Su, Bo-Rong Peng, Mei-Chin Lu, Jih-Jung Chen, Zhi-Hong Wen, Yang-Chang Wu, and Ping-Jyun Sung, Oxytoxin-2, An Algal-Derived Molecule from a Cultured Mollusc Volvatella vigourouxi, Natural Product Communications, 2016, Jul 11: 1783-1784. (SCI)

Ching-Chia Li, Juan-Cheng Yang, Mei-Chin Lu, Chia-Lin Lee, Chieh-Yu Peng, Wei-Yu Hsu, Yun-Hao Dai, Fang-Rong Chang, Da-Yong Zhang, Wen-Jeng Wu and Yang-Chang Wu, ATR-Chk1 signaling inhibition as a therapeutic strategy to enhance cisplatin chemosensitivity in urothelial bladder cancer, Oncotarget, 2016, Jan 12; 7(2):1947-59. (SCI)

Yu-Hsin Chen, Mei-Chin Lu, Hsu-Ming Chung, Ching-Feng Weng, Jui-Hsin Su, Yu-Tang Yang, Yin-Di Su, Yu-Chia Chang, Jimmy Kuo, Yang-Chang Wu, and Ping-Jyun Sung, Bafilomycin M, a new cytotoxic bafilomycin produced by a

Streptomyces sp. isolated from a marine sponge Theonella sp., Tetrahedron Letters, 2016, Sep 19; 57: 4863-4865. (Impact factor: 2.259; Ranking: 28/57=49.13% in chemistry, Organic, SCI)

Kai-Yu Peng, Nan-Fu Chen, Zhi-Cheng Chen, Kuan-Hao Tsui, Zhi-Hong Wen, Yin-Di Su, Yu-Chia Chang, Yu-Hsin Chen, Mei-Chin Lu, Lee-Shing Fang, Jih-Jung Chen, Tung-Ying Wu, Yang-Chang Wu, and Ping-Jyun Sung, Cladieunicellins R and S, new eunicellins from the Formosan octocoral Cladiella tuberculosa, Tetrahedron Letters, 2016, Aug 9; 57: 4239-4242. (Impact factor: 2.259; Ranking: 28/57=49.13% in chemistry, Organic, SCI)

Chiung-Yao Huang, Ping-Jyun Sung, Chokkalingam Uvarani, Jui-Hsin Su, Mei-Chin Lu, Tsong-Long Hwang, Chang-Feng Dai, Shwu-Li Wu, and Jyh-Horng Sheu, Glaucumolides A and B, Biscembranoids with New Structural Type from a Cultured Soft Coral Sarcophyton glaucum. Scientific Reports, 2015, Nov 4; 5:15624. (Impact factor: 4.011; Ranking: 10/64=21.01% in Multidisciplinary science, SCI)

Ya-Yuan Lai, Li-Chai Chen, Chug-Fung Wu, Mei-Chin Lu, Zhi-Hong Wen, Tung-Ying Wu, Lee-Shing Fang, Li-Hsueh Wang, Yang-Chang Wu, and Ping-Jyun Sung, New Cytotoxic 24-Homoscalarane Sesterterpenoids from the Sponge Ircinia felix. International Journal of Molecular Sciences, 2015, Sep 11; 16(9): 21950–21958. (Impact factor: 4.183; Ranking: 46/172=26.75% in Chemistry, Medicinal, SCI)

Tsen-Ni Tsai, Jia-Jing Ho, Maw-Shung Liu,  Tzu-Ying Lee,  Mei-Chin Lu,  Chia-Jen Liu,  Li-Ju Huang,  Sheng-I Lue,  and Rei-Chen Yang, Role of Exogenous Hsp72 on Liver Dysfunction during Sepsis. BioMed Research International, 2015, Jun 3; 2015:508101. (Impact factor: 2.197; Ranking: 94/162=58.03% in Biotechnology & Applied Microbiology, SCI)

Ting-His Hsiao, Ching-Hsiao Cheng, Tung-Ying Wu, Mei-Chin Lu, Wu-Fu Chen, Zhi-Hong Wen, Chang-Feng Dai, Yang-Chang Wu and Ping-Jyun Sung, New Cembranoid Diterpenes from the Cultured Octocoral Nephthea columnaris. Molecules, 2015, Jul 21; 20(7): 13205-13215. (Impact factor: 3.060; Ranking:68/172=39.54% in Chemistry, Organic, SCI)

Ya-Yuan Lai, Mei-Chin Lu, Li-Hsueh Wang, Jih-Jung Chen, Lee-Shing Fang, Yang- Chang Wu, and Ping-Jyun Sung, New Scalarane Sesterterpenoids from the Formosan Sponge Ircinia felix. Marine Drugs. 2015, Jul 14; 13(7): 4296–4309. (Impact factor: 3.772; Ranking: 5/59=23.77% in Chemistry, Medicinal, SCI)

Keh-Min Liu , Shu-Mien Chuang , Cheng‐Yu Long , Yi-Lun Lee , Chao-Chuan Wang , Mei-Chin Lu, Rong-Jyh Lin , Jian-He Lu , Mei-Yu Jang , Wen-Jeng Wu , Wan-Ting Ho , Yung-Shun Juan, Ketamine-induced ulcerative cystitis and bladder apoptosis involve oxidative stress mediated by mitochondria and endoplasmic reticulum. American Journal of Physiology - Renal Physiology, 2015, Aug 15; 309(4):F318-31. (Impact factor: 3.323 Ranking: 16/80=20.00% in Urology & Nephrology, SCI)

Tsen-Ni Tsai, Tzu-Ying Lee, Maw-Shung Liu, I-Chun Chuang, Mei-Chin Lu, Huei-Ping, Sheng-I Lue, and Rei-Chen Yang, Release of endogenous heat shock protein 72 on the survival of sepsis in rats. Journal of Surgical Research, 2015, May 7; 198(1):165-74. (Impact factor: 1.872; Ranking: 104/203=51.24% in Surgery, SCI)

Ting-His Hsiao, Chun-Sung Sung, Yu-Hsuan Lan, Yi-Chen Wang, Mei-Chin Lu, Zhi-Hong Wen, Yang-Chang Wu and Ping-Jyun Sung, New Anti-Inflammatory Cembranes from the Cultured Soft Coral Nephthea columnaris. Marine Drugs, 2015, May 29; 13(6): 3443-3453. (Impact factor: 3.772; Ranking: 5/59=23.77% in Chemistry, Medicinal, SCI)

Shou-Ping Shih, Man-Gang Lee, Mohamed El-Shazly, Yung-Shun Juan, Zhi-Hong Wen, Ying-Chi Du, Jui-Hsin Su, Ping-Jyun Sung, Yu-Cheng Chen, Juan-Cheng Yang, Yang-Chang Wu and Mei-Chin Lu*, Tackling the Cytotoxic Effect of a Marine Polycyclic Quinone-Type Metabolite: Halenaquinone Induces Molt 4 Cells Apoptosis via Oxidative Stress Combined with the Inhibition of HDAC and Topoisomerase Activities. Marine Drugs, 2015, May 20; 13(5): 3132–3153. (Impact factor: 3.772; Ranking: 5/59=23.77% in Chemistry, Medicinal, SCI) (通訊作者)

Tzu-Rong Su, Zuo-Jian Liao, Mei-Chin Lu, Yu-Jen Wu, and Jui-Hsin Su, Cytotoxic Monocarbocyclic Sesterterpenoids from a Marine Sponge Luffariella sp. Bulletin of the Chemical Society of Japan, 2015, Sep 26; 88:176-182. (SCI)

Kuan-Ming Liu, Ching-Hsiao Cheng, Wu-Fu Chen, Mei-Chin Lu, Lee-Shing Fang , Zhi-Hong Wen, Jui-Hsin Su, Yang-Chang Wu, and Ping-Jyun Sung. Trocheliolide A, a Hydroperoxycembranoidal Diterpene from the Octocoral Sarcophyton trocheliophorum. Natural Product Communications, 2015, Apr 7; 10:1163-1165. (SCI)

Wu-Fu Chen, Chen-Ting Yin, Ching-Hsiao Cheng, Mei-Chin Lu, Lee-Shing Fang, Wei-Hsien Wang, Zhi-Hong Wen, Jih-Jung Chen, Yang-Chang Wu, and Ping-Jyun Sung, Norcembranoidal Diterpenes from the Cultured-Type Octocoral Sinularia numerosa. International Journal of Molecular Sciences, 2015, Feb 3; 16(2): 3298–3306. (Impact factor: 4.183; Ranking: 46/172=26.75% in Chemistry, Medicinal, SCI)

Chi-Jen Tai, Uvarani Chokkalingam, Yang Cheng, Shou-Ping Shih, Mei-Chin Lu, Jui-Hsin Su, Tsong-Long Hwang  and Jyh-Horng Sheu; Krempfielins Q and R, Two New Eunicellin-Based Diterpenoids from the Soft Coral Cladiella krempfi, International Journal of Molecular Sciences, 2014, Nov 27; 15(12):21865-74. (Impact factor: 4.183; Ranking: 46/172=26.75% in Chemistry, Medicinal, SCI)

Yung-Shun Juan, Chien-Chih Lee, Chia-Wei Tsao, Mei-Chin Lu, Mohamed El-Shazly, Huei-Chuan Shih, Yu-Cheng Chen, Yang-Chang Wu and Jui-Hsin Su, Structure Elucidation and Cytotoxic Evaluation of New Polyacetylenes from a Marine Sponge Petrosia sp. International Journal of Molecular Sciences, 2014, Sep 18; 15: 16511-16521. (Impact factor: 4.183; Ranking: 46/172=26.75% in Chemistry, Medicinal, SCI)

Ching-Wen Chiu, Huey-Jen Su, Mei-Chin Lu, Wei-Hsien Wang, Jyh-Horng Sheu and Jui-Hsin Su, Cytotoxic Polyactylenes from a Formosan Marine Sponge Callyspongia sp. Bulletin of the Chemical Society of Japan, 2014, Jul 31; 87(11):1231-1234. (SCI)

Chao-Ying Kuo, Yung-Shun Juan, Mei-Chin Lu, Michael Yen-Nan Chiang, Chang-Feng Dai, Yang-Chang Wu, and Ping-Jyun Sung, Pregnane-type Steroids from the Formosan Soft Coral Scleronephthya flexilis, International Journal of Molecular Sciences, 2014, Jun 6; 15: 10136-10149. (Impact factor: 4.183; Ranking: 46/172=26.75% in Chemistry, Medicinal, SCI)

Huei-Chuan Shih, Mohamed El-Shazly, Yung-Shun Juan, Chao-Yuan Chang, Jui-Hsin Su, Yu-Cheng Chen, Shou-Ping Shih, Huei-Mei Chen, Yang-Chang Wu and Mei-Chin Lu*, Cracking the Cytotoxicity Code: Apoptotic Induction of 10-Acetylirciformonin B is Mediated through ROS Generation and Mitochondrial Dysfunction, Marine Drugs, 2014, May 22; 12:3072-3090. (Impact factor: 3.772; Ranking: 5/59=23.77% in Chemistry, Medicinal, SCI) (通訊作者)

Tsung-Hung Chen, Wu-Fu Chen, Zhi-Hong Wen, Mei-Chin Lu, Wei-Hsien Wang, Yang-Chang Wu and Ping-Jyun Sung; Cladieunicellin M-Q, a New Eunicellins from Cladiella sp., Marine drugs, 2014, Apr 8; 12(4):2144-2155. (Impact factor: 3.772; Ranking: 5/59=23.77% in Chemistry, Medicinal, SCI)

I.M. Ayoub, M. El-Shazly, M.-C. Lu, A.N.B. Sing; Antimicrobial and cytotoxic activities of the crude extracts of Dietes bicolor leaves, flowers and rhizomes, South African Journal of Botany, 2014, Aug 27; 95: 97–101. (Impact factor: 1.504; Ranking: 108/223=48.43% in Plant Sciences, SCI)

Tsung-Hung Chen, Ching-Hsiao Cheng, Yung-Husan Chen, Mei-Chin Lu, Lee-Shing Fang,Wu-Fu Chen, Zhi-Hong Wen, Wei-Hsien Wang, Yang-Chang Wu and Ping-Jyun Sung;  Cladieunicellin J, a New Hydroperoxyeunicellin from Cladiella sp., Natural Product Communications, 2014, Feb 19; 9(5):613-614. (SCI)

Wangta Liu, Kai-Ju Liang, Ching-Ying Chiang, Mei-Chin Lu, and Jui-Hsin Su; New nitrogenous bisabolene-type sesquiterpenes from a formosan sponge Axinyssa sp., Chemical & Pharmaceutical Bulletin (Tokyo), 2014, Jan 17; 62(4): 392-4. (SCI)

Su JH, Chen YC, El-Shazly M, Du YC, Su CW, Tsao CW, Liu LL, Chou YL, Chang WB, Su YD, Chiang M Y, Yeh YT and Lu MC*. Towards the small and the beautiful: a Small Dibromotyrosine Derivative from Pseudoceratina sp. Sponge Exhibits Potent Apoptotic Effect through Targeting IKK/NFκB Signaling Pathway. Marine Drugs, 2013, Aug 26; 11:3168-3185. (Impact factor: 3.772; Ranking: 5/59=23.77% in Chemistry, Medicinal, SCI) (通訊作者)

Hu LC, Su JH, Chiang MY, Lu MC, Hwang TL, Chen YH, Hu WP, Lin NC, Wang WH, Fang LS, Kuo YH, Sung PJ. Flexibilins A-C, new cembrane-type diterpenoids from the Formosan soft coral, Sinularia flexibilis. Marine Drugs, 2013, Jun 10; 11(6):1999-2012. (Impact factor: 3.772; Ranking: 5/59=23.77% in Chemistry, Medicinal, SCI)

Lin CY, Lu MC, Su JH, Chu CL, Shiuan D, Weng CF, Sung PJ, Huang KJ. Immunomodulatory effect of maine cembrane-typr diterpenoids on dendritic cells. Marine Drugs, 2013, Apr 22; 11(4):1336-50. (Impact factor: 3.772; Ranking: 5/59=23.77% in Chemistry, Medicinal, SCI)

Lu MC, El-Shazly M, Wu TY, Du YC, Chang TT, Chen CF, Hsu YM, Lai KH, Chiu CP, Chang FR, Wu YC. Recent research and development of Antrodia cinnamomea. Pharmacology & Therapeutics, 2013, Apr 4; 139(2):124-56. (Impact factor: 9.396; Ranking: 8/267=3.00 % in Pharmacology & Pharmacy, SCI )

Huang KJ, Chen YC, El-Shazly M, Du YC, Su JH, Tsao CW, Yen WH, Chang WB, Su YD, Yeh YT, Lu MC*. 5-Episinuleptolide acetate, a norcembranoidal diterpene from the formosan soft coral Sinularia sp., induces leukemia cell apoptosis through Hsp 90 inhibition. Molecules, 2013, Mar 4; 18(3):2924-33. (Impact factor: 3.060; Ranking:68/172=39.54% in Chemistry, Organic, SCI)

Yen WH, Chen WF, Cheng CH, Dai CF, Lu MC, Su JH, Su YD, Chen YH, Chang YC, Chen YH, Sheu JH, Lin CH, Wen ZH, Sung PJ. A new 5α,8α- Epidioxysterol from the soft coral Sinularia gaweli. Molecules, 2013, Mar 4; 18(3):2895-903. (Impact factor: 3.060; Ranking:68/172=39.54% in Chemistry, Organic, SCI)

Yen WH, Hu LC, Su JH, Lu MC, Twan WH, Yang SY, Kuo YC, Weng CF, Lee CH, Kuo YH, Sung PJ. Norcembranoidal diterpenes from a Formosan soft coral Sinularia sp. Molecules, 2012, Nov 27; 17(12):14058-66. (Impact factor: 3.060; Ranking:68/172=39.54% in Chemistry, Organic, SCI)

Chung HM, Hu LC, Yen WH, Su JH, Lu MC, Hwang TL, Wang WH, Sung PJ. Echinohalimane A, a bioactive halimane-type diterpenoid from a Formosan gorgonian Echinomuricea sp. (Plexauridae). Marine Drugs, 2012, Oct. 17, 10(10): 2246-53. (Impact factor: 3.772; Ranking: 5/59=23.77% in Chemistry, Medicinal, SCI)

Su JH, Chang WB, Chen HM, EI-Shazly M, Du YC, Kung TH, Chen YC, Sung PJ, Ho YS, Ko FW, and Lu MC*. 10-acetylirciformonin B, a sponge furanoterpenoid, induces DNA damage and apoptosis in leukemia cells, Molecules, 2012, Oct. 9, 17(10):11839-48. (Impact factor: 3.060; Ranking:68/172=39.54% in Chemistry, Organic, SCI)

Chen YH, Kuo J, Sung PJ, Chang YC, Lu MC, Wong TY, Liu JK, Weng CF, Twan WH, Kuo FW. Isolation of marine bacteria with antimicrobial activities from cultured and field-collected soft corals. World Journal of Microbiology & Biotechnology. 2012, Aug. 8, 28(12):3269 - 79. (Impact factor: 2.652; Ranking: 70/162=43.21% in Biotechnology & Applied microbiology, SCI)

Cheng CH, Chung HM, Hwang TL, Lu MC, Wen ZH, Kuo YH, Wang WH, Sung PJ. Echinoclerodane A: a new bioactive clerodane-type diterpenoid from a gorgonian coral Echinomuricea sp. Molecules, 2012, Aug. 7, 17(8):9443-50. (Impact factor: 3.060; Ranking:68/172=39.54% in Chemistry, Organic, SCI)

Guo JK, Chiang CY, Lu MC, Chang WB, Su JH. 4-Methylenesterols from a sponge Theonella swinhoei. Marine Drugs, 2012, Jul. 19, 10(7):1536-44. (Impact factor: 3.772; Ranking: 5/59=23.77% in Chemistry, Medicinal, SCI)

Chung HM, Hong PH, Su JH, Hwang TL, Lu MC, Fang LS, Wu YC, Li JJ, Chen JJ, Wang WH, Sung PJ. Bioactive compounds from a gorgonian coral Echinomuricea sp. (Plexauridae). Marine Drugs, 2012, May 10, 10(5):1169-79. (Impact factor: 3.772; Ranking: 5/59=23.77% in Chemistry, Medicinal, SCI)

Chang YC, Tseng SW, Liu LL, Chou Y, Ho YS, Lu MC, Su JH. Cytotoxic sesterterpenoids from a sponge Hippospongia sp. Marine Drugs, 2012, May 10, 10(5):987-97. (Impact factor: 3.772; Ranking: 5/59=23.77% in Chemistry, Medicinal, SCI)

Lin YS, Lee NL, Lu MC, Su JH. Two new cembrane-based diterpenoids from the marine soft coral Sinularia crassa. Molecules, 2012, May 8, 17(5):5422-9. (Impact factor: 3.060; Ranking:68/172=39.54% in Chemistry, Organic, SCI)

Du YC, Chang FR, Wu TY, Hsu YM, El-Shazly M, Chen CF, Sung PJ, Lin YY, Lin YH, Wu YC, Lu MC*. Antileukemia component, dehydroeburicoic acid from Antrodia camphorata induces DNA damage and apoptosis in vitro and in vivo models. Phytomedicine, 2012, Jun 15, 19(8-9): 788-96. (Impact factor: 4.180; Ranking: 1/27=3.71% in Integrative & Complementary Medicine, SCI)

Wu YC, Su JH, Chou TT, Cheng YP, Weng CF, Lee CH, Fang LS, Wang WH, Li JJ, Lu MC, Kuo J, Sheu JH, Sung PJ. Natural product chemistry of gorgonian corals of genus Junceella--part II. Marine Drugs, 2011, Dec. 19, 9(12):2773-92. (Impact factor: 3.772; Ranking: 5/59=23.77% in Chemistry, Medicinal, SCI)

Du YC, Wu TY, Chang FR, Lin WY, Hsu YM, Cheng FT, Lu CY, Yen MH, Tsui YT, Chen HL, Hou MF, Lu MC*, Wu YC*., Chemical profiling of the cytotoxic triterpenoid-concentrating fraction and characterization of ergostane stereo-isomer ingredients from Antrodia camphorata. Journal of pharmaceutical and biomedical analysis , 2012, Sep. 16, 58:182-92. (Impact factor: 2.983; Ranking: 24/84=28.58% in Chemistry& Analytical, SCI)

Su JH, Tseng SW, Lu MC, Liu LL, Chou Y, Sung PJ. Cytotoxic C21 and C22 terpenoid-derived metabolites from the sponge Ircinia sp. Journal of Natural Products, 2011, Sep 23, 74(9):2005-9. (Impact factor: 4.257; Ranking: 16/228=7.02% in Plant sciences, SCI)

Lu MC, Lee NL, Tseng SW, and JH Su. Sinutriangulin A, a novel diterpenoid from the soft coral Sinularia triangula. Tetrahedron Letters, 2011, Sep. 2, 52: 5869-5871. (Impact factor: 2.259; Ranking: 28/57=49.13% in Chemistry, organic, SCI )

Kao CY, Su JH, Lu MC, Hwang TL, Wang WH, Chen JJ, Sheu JH, Kuo YH, Weng CF, Fang LS, Wen ZH, Sung PJ. Lobocrassins A-E: new cembrane-type diterpenoids from the soft coral Lobophytum crassum. Marine Drugs, 2011, Aug 5, 9(8):1319-31. (Impact factor: 3.772; Ranking: 5/59=23.77% in Chemistry, Medicinal, SCI)

Kao SY, Chang YC, Su JH, Lu MC, Chen YH, Sheu JH, Wen ZH, Wang WH, Kuo YH, Hwang TL, Sung PJ. (-)-Hydroxylindestrenolide, a new sesquiterpenoid from a gorgonian coral Menella sp. (Plexauridae). Chem. Pharm. Bull., 2011, Aug. 1, 59(8):1048-50. (SCI)

Chen YH, Tai CY, Su YD, Chang YC, Lu MC, Weng CF, Su JH, Hwang TL, Wu YC, Sung PJ. Discovery of new eunicellins from an Indonesian octocoral Cladiella sp. Marine Drugs, 2011, May 26, 9(6):934-43. (Impact factor: 3.772; Ranking: 5/59=23.77% in Chemistry, Medicinal, SCI)

Yang JC, Lu MC, Lee CL, Chen GY, Lin YY, Chang FR, Wu YC. Selective targeting of breast cancer cells through ROS-mediated mechanisms potentiates the lethality of paclitaxel by a novel diterpene, gelomulide K. Free Radic. Biol. Med. 2011, Aug 1, 51(3):641-57. (Impact factor: 5.657; Ranking: 43/298=14.43% in Biochemistry & Molecular Biology, SCI)

 


專書及專書論文

蘇瑞欣、呂美津、宋秉鈞,臺灣珊瑚所含活性物質 珊瑚世界的探索與了解。國立海洋生物博物館,2011,P76-P83, ISBN 9789860302646。

張東柱、吳永昌、張芳榮、陳介甫、呂美津、王隆耀、蔡東榮、蔣文欽、杜英齊、洪志昇、吳東穎、Mohamed El-Shazly、許育銘、賴奎宏、邱錦朋、鄭富庭、何孟琦,2015年11月,新圖解牛樟菇,ISBN 978-986-91187-5-0 (平裝),活石文化事業有限公司,頁數128。

 


研討會論文

Yi-Chang Liu; Po-Shun Chen; Kai-Cheng Hsu; Yu-Hsuan Lin; Yi-Hsin Lin; Shou-Ping Shih; Leng-Chiang Chien; Yi-Jia Hong; Hung-Yu Lin; Mei-Chin Lu*, The Antitumor Effect of 13-Acetoxysarcocrassolide, a Cytotoxic Cembranolide Derivative, Against Oral Cancer Cells is Through the Regulation of Nrf2/Keap1/p62/SQSTM1 pathway. 201910 The 34th Symposium of Natural Products. 中華民國 長庚科技大學.

Shou-Ping Shih; Po-Shun Chen; Yu-Hsuan Lin; Yi-Hsin Lin; Chun-Lin Chen; Steve Sheng-Fa Yu; Mei-Chin Lu*, Antileukemia effect of Xestoquinone, induced apoptosis via oxidative stress combined with inhibition of Hsp90 and Topoisomerase II activities. 201910 The 34th Symposium of Natural Products. 中華民國 長庚科技大學.

Young-Shiou Lin; Wei-Lun Qiu; Shou-Ping Shih; Mei-Chin Lu*, Anti-prostate cancer mechanism of Lu01-M extract from marine actinomycete, Streptomyces sp. 201906第八屆海洋中的"奧秘"國際研討會. 中華民國 國立海洋生物博物館.

Shou-Ping Shih; Mei-Chin Lu*; Chun-Lin Chen; Steve Sheng-Fa Yu, Antileukemia effect of Xestoquinone, induced apoptosis via oxidative stress combined with inhibition of Hsp90 and Topoisomerase II activities. 201906第八屆海洋中的"奧秘"國際研討會. 中華民國 國立海洋生物博物館.

Yu-Cheng Chen, Mohamed El-Shazly, Jui-Hsin Su, Ping-Jyun Sung, Tung-Ying Wu , Yang-Chang Wu, and Mei-Chin Lu*, Heteronemin, a Sesterterpene Derivative, Induces Apoptosis in Leukemia Molt4 cells Through Oxidative Stress, Mitochondrial Dysfunction and Induction of Talin Expression. 201804墾丁國家公園珊瑚礁生態保育週.

Shou-Ping Shih; Yu-Cheng Chen; You-Ying Chen;Yi-Cheng Chou; Young-Shiou Lin; Chieh-Yu Lee;Chun-Lin Chen; Mei-Chin Lu*, Cytotoxic Molecular Targets of Heteronemin, Induced Prostate Cancer LNcap Cells Apoptosis via Inhibitory Effects on Hsp90 and Topoisomerase Activities. 201804墾丁國家公園珊瑚礁生態保育週.

林詠琇;陳又誠;施守平;陳又瀅;周依橙;李婕瑜;呂美津*,藉由海洋放線菌Streptomyces sp. 萃取物AG01-M之抗前列腺癌機制探討. 201804墾丁國家公園珊瑚礁生態保育週.

Bo-Rong Peng, Yi-Cheng Chou,You-Ying Chen,Shou-Ping Shih ,Ping-Jyun Sung, and Mei-Chin Lu*, 13-Acetoxysarcocrassolide, a Cytotoxic Cembranolide Derivative, Exhibited Apoptotic Activity on Oral Cancer Cells through the Inhibition of Heat Shock Protein 90. 201806, 2018臺灣海洋生物技術學會第三屆第二次會員大會暨「海洋生物技術創新應用研討會」.國立高雄科技大學(楠梓校區)(博士組壁報競賽第一名)

Yu-Cheng Chen , Mohamed El-Shazly , Jui-Hsin Su , Ping-Jyun Sung , Tung-Ying Wu  , Yang-Chang Wu, and Mei-Chin Lu*, Breaking Down Leukemia Walls: Heteronemin, a Sesterterpene Derivative, Induces Apoptosis in Leukemia Molt4 cells Through Oxidative Stress, Mitochondrial Dysfunction and Induction of Talin Expression. 201806, 2018臺灣海洋生物技術學會第三屆第二次會員大會暨「海洋生物技術創新應用研討會」.國立高雄科技大學(楠梓校區)(博士組壁報競賽第一名)

Yong-Shiou Lin, Yu-Cheng Chen, Shou-Ping Shih, You-Ying Chen, Yi-Cheng Chou, Chieh-Yu Lee, and Mei-Chin Lu*, Anti-prostate cancer mechanism of AG01-M,extract from Marine Actinomycete, Streptomyces sp.. 201806, 2018臺灣海洋生物技術學會第三屆第二次會員大會暨「海洋生物技術創新應用研討會」.國立高雄科技大學(楠梓校區)(碩士組壁報競賽佳作)

You-Ying Chen, Shou-Ping Shih, Chieh-Yu Lee, Chun-Lin Chen, Steve Sheng-Fa Yu, and Mei-Chin Lu*, Antileukemia effect of Xestoquinone, induced apoptosis via oxidative stress combined with inhibition of Hsp90 and Topoisomerase II activities. 201806, 2018臺灣海洋生物技術學會第三屆第二次會員大會暨「海洋生物技術創新應用研討會」.國立高雄科技大學(楠梓校區)(博士組壁報競賽第三名)

You-Ying Chen, Yi-Cheng Chou, Bo-Rong Peng, Shou-Ping Shih, Mei-Chin Lu*, 13-Acetoxysarcocrassolide, a Cytotoxic Cembranolide Derivative, Exhibited Apoptotic Activity on Oral Cancer Cells through the Inhibition of Heat Shock Protein 90. 201808 The 66th Annual Meeting of the Society for Medicinal Plant and Natural Product Research (GA). Shanghai, China.

Mei-Chin Lu*, You-Ying Chen, Shou-Ping Shih, Bo-Rong Peng, Heteronemin, a Marine Sesterterpenoid-Type Metabolite,Induces Apoptosis in Prostate LNcap Cells via Oxidative and ER Stress. 201808 The 66th Annual Meeting of the Society for Medicinal Plant and Natural Product Research (GA). Shanghai, China.

Bo-Rong Peng, Yu-Cheng Chen, Ping-jyun Sung, Mei-Chin Lu*, Heteronemin, Induced Mitochondrial Superoxide Production and Cytoskeleten protein Talin Dysfunction Mediated Leukemia Molt 4 cells Apoptosis. 201808 The 66th Annual Meeting of the Society for Medicinal Plant and Natural Product Research (GA). Shanghai, China.

Shou-Ping Shih, You-Ying Chen, Chun-Lin Chen, Steve Sheng-Fa Yu*, Mei-Chin Lu*, Antileukemia effect of Xestoquinone, induced apoptosis via oxidative stress combined with inhibition of Hsp90 and topoisomerase II activities. 201808 The 66th Annual Meeting of the Society for Medicinal Plant and Natural Product Research (GA). Shanghai, China.

Yu-Cheng Chen, Mohamed El-Shazly, Jui-Hsin Su , Ping-Jyun Sung, Tung-Ying Wu , Yang-Chang Wu, and Mei-Chin Lu*, Breaking Down Leukemia Walls: Heteronemin, a Sesterterpene Derivative, Induces Apoptosis in Leukemia Molt4 cells Through Oxidative Stress, Mitochondrial Dysfunction and Induction of Talin Expression. 201809 2018癌症生物與藥研發博士學位學程學術研討會. 中華民國 中央研究院.

Shou-Ping Shih, Yi-Chang Liu, Ming-Chang Hong, Ying-Chi Du, Ping-Jyun Sung, Mei-Chin Lu*, Heteronemin, a Marine Sesterterpenoid-Type Metabolite, Induces Apoptosis in Prostate LNcap Cells via Oxidative and ER Stress Combined with the Inhibition of Topoisomerase Ⅱ and Hsp90. 201810 第33屆天然藥物國際研討會.中華民國 高雄醫學大學.

Shou-Ping Shih, You-Ying Chen, Chun-Lin Chen, Steve Sheng-Fa Yu, Mei-Chin Lu*, Antileukemia effect of Xestoquinone, induced apoptosis via oxidative stress combined with inhibition of Hsp90 and Topoisomerase II activities. 201810 第33屆天然藥物國際研討會.中華民國 高雄醫學大學.

Chieh-Yu Lee, Shou-Ping Shih, Yu-Cheng Chen, You-Ying Chen, Mei-Chin Lu*, FY01, an extraction from marine microorganism Streptomyces sp. induced prostate cancer cell apoptosis through mitochondrial dysfunction and induction of ROS generation. 201810 第33屆天然藥物國際研討會.中華民國 高雄醫學大學.

You-Ying Chen, Bo-Rong Peng, Shou-Ping Shih, Zhi-Hong Wen, Mei-Chin Lu*, 13-Acetoxysarcocrassolide, a Cytotoxic Cembranolide Derivative, Induced Apoptotic Activity on leukemia Cancer Cells through the Oxidative Stress. 201810 第33屆天然藥物國際研討會.中華民國 高雄醫學大學.

Yu-Cheng Chen, Mohamed El-Shazly, Jui-Hsin Su , Ping-Jyun Sung, Tung-Ying Wu , Yang-Chang Wu, and Mei-Chin Lu*, Breaking Down Leukemia Walls: Heteronemin, a Sesterterpene Derivative, Induces Apoptosis in Leukemia Molt4 cells Through Oxidative Stress, Mitochondrial Dysfunction and Induction of Talin Expression. 201810 第33屆天然藥物國際研討會.中華民國 高雄醫學大學.

Yi-Cheng Chou, Bo-Rong Peng, Jui-Hsin Su, Yu-Cheng Chen, Shou-Ping Shih, Young-Shiou Lin, and Mei-Chin Lu. Disruption of Mitochondrial Membrane Potential and Overproduction of Reactive Oxygen Species Leads to Apoptosis in Ca9-22 Cells in Response to 13-Acetoxysarcocrassolide. The 7th International Symposium for Marine Biology and Biotechnology, Sep. 21-22, 2016. National Museum of Marine Biology & Aquarium, Taiwan.

Young-Shiou Lin, Yu-Cheng Chen, Shou-Ping Shih, Yi-Cheng Chou, Ping-Jyun Sung, and Mei-Chin Lu. Isoaaptamine, an alkaloid, isolated from the marine sponge Aaptos sp., induces apoptosis through the disruption of mitochondrial membrane potential and induction of endoplasmic reticulum stress. The 7th International Symposium for Marine Biology and Biotechnology, Sep. 21-22, 2016. National Museum of Marine Biology & Aquarium, Taiwan.

Kuei-Hung Lai, Mei-Chin Lu, Jui-Hsin Su, Yu-Ming Hsu, Mohamed El-Shazly, Ying-Chi Du, Yu-Che Chuang, Shu-Li Chen, Chy-Jia Wang, Ming-Yuan Hung, Fang-Rong Chang, Yang-Chang Wu, and Anders Backlund. Separation and Identification on Stereoisomers of Manoalide and Luffariellin Derivatives and Their Configuration-depending Antileukemic Effects In Vitro and In Vivo. The 7th International Symposium for Marine Biology and Biotechnology, Sep. 21-22, 2016. National Museum of Marine Biology & Aquarium, Taiwan.

Yi-Cheng Chou, Bo-Rong Peng, Jui-Hsin Su, Yu-Cheng Chen, Shou-Ping Shih, Young-Shiou Lin, Kuan-Chih Wang, and Mei-Chin Lu. Disruption of Mitochondrial Membrane Potential and Overproduction of Reactive Oxygen Species Leads to Apoptosis in Ca9-22 Cells in Response to 13-Acetoxysarcocrassolide. The 31th Symposium on Natural Product & Symposium on Pharmacy and Traditional Chinese Medicine, Oct. 14-15, 2016. National Sun Yat-Sen University, Taiwan.

Young-Shiou Lin, Yu-Cheng Chen, Shou-Ping Shih, Yi-Cheng Chou, Ping-Jyun Sung, Kuan-Chih Wang, and Mei-Chin Lu. Isoaaptamine, an alkaloid, isolated from the marine sponge Aaptos sp., induces apoptosis through the disruption of mitochondrial membrane potential and induction of endoplasmic reticulum stress. The 31th Symposium on Natural Product & Symposium on Pharmacy and Traditional Chinese Medicine, Oct. 14-15, 2016. National Sun Yat-Sen University, Taiwan.

Kuei-Hung Lai, Mei-Chin Lu, Jui-Hsin Su, Yu-Ming Hsu, Mohamed El-Shazly, Ying-Chi Du, Yu-Che Chuang, Shu-Li Chen, Chy-Jia Wang, Ming-Yuan Hung, Fang-Rong Chang, Yang-Chang Wu, and Anders Backlund. Separation and Identification on Stereoisomers of Manoalide and Luffariellin Derivatives and Their Configuration-depending Antileukemic Effects In Vitro and In Vivo. The 31th Symposium on Natural Product & Symposium on Pharmacy and Traditional Chinese Medicine, Oct. 14-15, 2016. National Sun Yat-Sen University, Taiwan. (第一名)

Kuei-Hung Lai, Mei-Chin Lu, Fang-Rong Chang, Jui-Hsin Su, Mohamed El-Shazly, Ying-Chi Du, Tung-Ying Wu, Yu-Ming Hsu, Anders Backlund and Yang-Chang Wu. Antileukemic sesterterpenoids from a marine sponge, Luffariell sp.. 9th Joint Natural Products Conference, Jul. 24-27, 2016. Copenhagen, Denmark.

Kuei-Hung Lai, Anders Backlund, Mei-Chin Lu, Ying-Chi Du, Mohamed El-Shazly, Tung-Ying Wu, Yu-Ming Hsu, Astrid Henz, Fang-Rong Chang, Yang-Chang Wu. Antileukemic lanostanoids from Poria cocos. The 63rd International Congress and Annual Meeting of the Society for Medicinal Plant and Natural Product Research (GA), Aug. 23-27, 2015. Budapest, Hungary.

謝寶全、呂美津、李宗遠. 憂遁草萃取物之化學分析及對淋巴癌SUP-T1細胞毒殺活性之研究, 2015, 植化素與健康國際研討會,March 3th, 台灣大學, 台北,台灣

Yu-Cheng Chen; Ru-Yi Chen; Mohamed El-Shazly; Shou-Ping Shih; Yi-Cheng Chou;  Young-Shiou Lin; Mei-Chin Lu, Using marine microorganism metabolites to establish the potential platform for development of anticancer drug candidates., The 6th  Symposium for Marine Biology and Biology, Sep. 16-18, 2015. National Museum of Marine Biology & Aquarium, Taiwan.

Man-Gang Lee; Shou-Ping Shih; Yu-Cheng Chen; Mohamed El-Shazly; Yi-Cheng Chou; Young-Shiou Lin; Ru-Yi Chen; Mei-Chin Lu, Cytotoxic Molecular Targets of  Heteronemin, Isolated from Sponge Hippospongia sp., in Human Prostate Cancer LNcap Cells. The 6th Symposium for Marine Biology and Biology, Sep. 16-18, 2015. National Museum of Marine Biology & Aquarium, Taiwan.

Yi-Cheng Chou; Young-Shiou Lin; Mohamed El-Shazly; Shou-Ping Shih; Yu-Cheng Chen; Ru-Yi Chen; Mei-Chin Lu, Isoaaptamine, Isolated from Sponge Aaptos sp., Induces Apoptosis in Molt 4 cells through the Disruption of MMP and Induction of ER‐Stress, The 6th Symposium for Marine Biology and Biology, Sep. 16-18, 2015. National Museum of Marine Biology & Aquarium, Taiwan.

Kuei-Hung Lai, Ying-Chi Du, Tung-Ying Wu, Yu-Ming Hsu, Mohame El-Shazly, You-Cheng Lin, Yu-Che Chuang, Tun-Tschu Chang, Mei-Chin Lu* and Yang-Chang Wu*. Dehydroeburicoic acid, an antileukemic triterpene from the fruiting bodies of dish-cultured Antrodia cinnamomea, 2014, International Symposium and Workshop on Medical Mushroom: Antrodia cinnamomea, May 27-29. Academia Sinica, Taipei. (第一名)

Yu-Ming Hsu, Ying-Chi Du, Tung-Ying Wu, Kuei-Hung Lai, Mohame El-Shazly, You-Cheng Lin,Tun-Tschu Chang, Mei-Chin Lu* and Yang-Chang Wu*. New Extraction and Seperation Procedure of Anti-tumor Triterpenoids and Immunostimulatory Polysaccharides from Dish-Cultured Antrodia cinnamomea , 2014,  International Symposium and Workshop on Medical Mushroom: Antrodia cinnamomea, May 27-29. Academia Sinica, Taipei.

Shou-Ping Shih, Mohamed El-Shazly, Ying-Chi Du, Jui-Hsin Su, Yu-Cheng Chen, Jia-Wei Jhou, Yang-Chang Wu* and Mei-Chin Lu*. Halenaquinone Induces Apoptosis in Leukemia Molt4 Cells by the Inhibition of Histone Deacetylase Activity and the Overproduction of Reactive Oxygen Species, The 29th Symposium on Natural Products, Sep. 27-28, 2014. Kaohsiung Medical University, Kaohsiung, Taiwan.

Yu-Cheng Chen, Mohamed El-Shazly, Ying-Chi Du, Jui-Hsin Su, Shou-Ping Shih, Jia-Wei Jhou, Yang-Chang Wu* and Mei-Chin Lu*. Heteronemin Induces Apoptosis in Leukemia Molt4 Cells by the Inhibition of Topoisomerase II and the Overproduction of Reactive Oxygen Species, The 29th Symposium on Natural Products, Sep. 27-28, 2014. Kaohsiung Medical University, Kaohsiung, Taiwan.

Chia-Wei Tsao , Shou-Ping Shih, Yu-Cheng Chen, Chiang-Wen Su, Jui - Hsin Su, Mei-Chin Lu * and Huei-Mei Chen*, Cytotoxic Polyacetylenes derived from a Marine Sponge petrosia sp. The Omics in the Ocean-The 5th International Symposium for Marine Biology and Biotechnology (海洋中的奧秘– 第五屆國際海洋生物及生物科技研討會)。Sep. 16~18. 2013,屏東,國立海洋生物博物館。

Shou-Ping Shih, Zuo-Jian Liao, Yu-Cheng Chen, Chiang-Wen Su, Chia-Wei Tsao, Jui-Hsin Su, Mei-Chin Lu * and Huei-Mei Chen*, Cytotoxic Effect of Marine Natural Products, Xestoquinone and Halenaquinone. The Omics in the Ocean-The 5th International Symposium for Marine Biology and Biotechnology (海洋中的奧秘– 第五屆國際海洋生物及生物科技研討會)。Sep. 16~18. 2013,屏東,國立海洋生物博物館。

Huei-Mei Chen, Yu-Cheng Chen , Chiang-Wen Su,  Chia-Wei Tsao, Shou-Ping Shih, Jui-Hsin Su, and Mei-Chin Lu *, Towards the Small and the Beautiful: A Small Dibromotyrosine Derivative from Pseudoceratina sp. Sponge Exhibits Potent Apoptotic Effect through Targeting IKK / NFκB Signaling Pathway. The Omics in the Ocean-The 5th International Symposium for Marine Biology and Biotechnology (海洋中的奧秘– 第五屆國際海洋生物及生物科技研討會)。Sep. 16~18. 2013,屏東,國立海洋生物博物館。

Yu-Cheng Chen, Shou-Ping Shih, Chiang-Wen Su, Chia-Wei Tsao, Jui-Hsin Su, Mei-Chin Lu * and Huei-Mei Chen*, Antileukemia effect of Marine Natural Product, Heteronemin, Induced Mitochondrial Dysfunction through Oxidative Stress. The Omics in the Ocean-The 5th International Symposium for Marine Biology and Biotechnology (海洋中的奧秘– 第五屆國際海洋生物及生物科技研討會)。Sep. 16~18. 2013,屏東,國立海洋生物博物館。

Chiang-Wen Su, Yu-Chia Chang, Ping-Jyun Sung, Shou-Ping Shih, Chia - Wei Tsao, Jui-Hsin Su, Mei-Chin Lu * and Huei-Mei Chen*, Isoaaptamine, a marine alkylating agent, induce DNA damage and autophagic cell death in breast cancer t-47D cells. The Omics in the Ocean-The 5th International Symposium for Marine Biology and Biotechnology (海洋中的奧秘– 第五屆國際海洋生物及生物科技研討會)。Sep. 16~18. 2013,屏東,國立海洋生物博物館。

Kuei-Hung Lai, Ying-Chi Du, Mei-Chin Lu, Tung-Ying Wu, Yu-Ming Hsu, You-Cheng Lin, Mohamed El-Shazly, Tzu-Shou Chu, Chieh-Fu Chen, Fang-Rong Chang *, and Yang-Chang Wu*. Dehydroeburicoic acid, an antileukemic triterpene from the fruiting bodies of dish-cultured Antrodia Cinnamomea. International Congress on Natural Products Research. Jul.28~Aug.1. 2012, New York. ( Planta Med 2012; 78 - PD52 DOI: 10.1055/s-0032-1320410.)

Ting-Hsuan Kung, You-Cheng Chen, Yi-Shin Lin, Huei-Mei Chen, Mei-Chin Lu*. Manoalide, marine sesterterpenen, induced apoptosis in leukaemia cells through generatioj of ROS and inhibition of Topo Ⅱ activity. Symposium on Natural Products Chemistry for Graduate Students. May 18~19. 2011, ,屏東,國立海洋生物博物館.

You-Cheng Chen, Ting-Hsuan Kung, Yi-Shin Lin, Mei-Chin Lu*. Heteronemin, a sponge sesterterpenoid, induces DNA damage and apoptosis through inhibition of HDAC and ROS generation. Symposium on Natural Products Chemistry for Graduate Students. May 18~19. 2012, ,屏東,國立海洋生物博物館.

Ying-Chi Du, You-Cheng Lin, Yen-Chi Chen, Yang-Chang Wu, Fang-Rong Chang, Tung-Ying Wu, Mohamed El-Shazly, Yu-Ming Hsu, Kuei-Hung Lai, Mei-Chin Lu, Tzu-Shou Chu, and Chieh-Fu Chen. New extraction and separation procedure for the large scale production of triterpenoids from dish-cultured Antrodia cinnamomea. The 27th Symposium on Natural Products, Oct. 6 ~7, 2012. Kaohsiung Medical University, Kaohsiung, Taiwan.

Mei-Chin Lu, Yu-Ming Hsu, Tung-Ying Wu, Kuei-Hung Lai, Ying-Chi Du, Mohamed El-Shazly, Tzu-Shou Chu, Chieh-Fu Chen, You-Cheng Lin, Fang-Rong Chang and Yang-Chang Wu. Evaluation for the antiproliferation and immunostimulatory activities of characteristic extracts from dish-cultured and wild Antrodia cinnamomea. The 27th Symposium on Natural Products, Oct. 6 ~7, 2012. Kaohsiung Medical University, Kaohsiung, Taiwan.

Ting-Hsuan Kung, Yu-Cheng Chen, Jui-Hsin Su, Shang-Wei Tseng,Chun-Ho Chu, Mei-Chin Lu*, 10-acetylirciformonin B, a new spongean sesterterpenoid, induces leukemia cells DNA damage and apoptosis. The Omics in the Ocean-The 3rd International Symposium for Marine Biology and Biotechnology (海洋中的奧秘–第三屆國際海洋生物及生物科技研討會)。Sep. 21~23. 2011,屏東,國立海洋生物博物館。

Ting-Hsuan Kung, Yu-Cheng Chen, Jui-Hsin Su, Shang-Wei Tseng,Chun-Ho Chu, Mei-Chin Lu*, 10-acetylirciformonin B, a new spongean sesterterpenoid, induces leukemia cells DNA damage and apoptosis. International Symposium on Traditional Chinese Medicine 2011 & The 26th Symposium on Natural Products (建國100 年國際中醫藥學術研討會暨第二十六屆天然藥物研討會), Oct. 29 ~ 30, 2011. China Medical University, Taichung, Taiwan.

Mei-Chin Lu, Ying-Chi Du, Tung-Ying Wu, Yu-Ming Hsu, Kuei-Hung Lai, Tzu -Shou Chu, Chieh-Fu Chen, Wan-Yu Lin, You-Cheng Lin, Mohamed EI- Shazly, Fang-Rong Chang, and Yang-Chang Wu, A chemical and bioactive triterpenoid marker platform of Antrodia cinnamomea. International Symposium on Traditional Chinese Medicine 2011 & The 26th Symposium on Natural Products (建國100 年國際中醫藥學術研討會暨第二十六屆天然藥物研討會), Oct. 29~Oct. 30, 2011. China Medical University, Taichung, Taiwan.

Tung-Ying Wu, Ying-Chi Du, Yu-Ming Hsu, Wan-Yu Lin, Chyi-Jia Wang, Mei-Chin Lu, Shu-Li Chen, and Fang-Rong Chang. Characterization and quantification of Antrodia camphorate benzenoid components with HPLC-PDA/MS and NMR. International Symposium on Traditional Chinese Medicine 2011 & The 26th Symposium on Natural Products (建國100 年國際中醫藥學術研討會暨第二十六屆天然藥物研討會), Oct. 29~Oct. 30, 2011. China Medical University, Taichung, Taiwan.

 


其他著作或專利

Manoalide衍生物異構物的分離及鑑定、以及其構型依賴抗血癌與抗淋巴癌功效 (呂美津、宋秉鈞、蘇瑞欣、賴奎宏、劉益昌、杜英齊、許育銘、郭富雯) (台灣發明專利,發明第I642665號)

用於治療癌症的Scalarane二倍半萜類、醫藥組合物及拓樸異構酶II抑制劑及其用途與製備方法(呂美津、宋秉鈞、蘇瑞欣、賴奎宏、劉益昌、杜英齊、許育銘、翁銘楷) (台灣發明專利,發明第I651088號)

SCALARANE SESTERTERPENOID, PHARMACEUTICAL COMPOSITION AND TOPOISOMERASE II AND HSP90 INHIBITOR FOR TREATING CANCER, AND USE AND PREPARATION METHOD THEREOF (Mei-Chin Lu; Ping-Jyun Sung; Jui-Hsin Su; Kuei-Hung Lai; Yi-Chang Liu; Ying-Chi Du; Yu-Ming Hsu; Ming-Kai Weng; Fu-Wen Kuo) (U.S. Patent No. 10,314,847) 2019/06/11~2037/08/14.

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